急性白血病患者血浆VEGF测定及临床意义

Determination and clinical significance of plasma VEGF in patients with acute leukemia

目的研究血清中血管内皮生长因子(VEGF)检测在白血病患者发病及缓解过程中的见后变化及其临床意义。方法收集30例急性白血病患者作为观察组,18名健康人作为对照组,应用酶联免疫技术(ELISA法)检测两组血清中VEGF浓度。结果急性白血病患者血清VEGF浓度显著高于正常人组(P<0.05),化疗前血清VEGF水平较对照组和完全缓解组明显升高(P<0.05),而完全缓解组与对照组的血清VEGF水平无显著性差异(P>0.05),其部分复发患者再次出现上述改变。结论急性白血病的发生与发展与血管内皮生长因子水平密切相关。

Objective To study the changes ant clinical significance of change and its clinical significance serum vascular endothelial growth factor （VEGF） detection and mitigation of disease in leukemia patients. Methods Totally 30 patients with acute leukemia as the observation group, 18 healthy people as control group, enzyme -linked imnmnoassay （ELISA） were detected in serum VEGF concentration. Results Serum VEGF concentrations in patients with acute leukemia was significantly higher than that of the normal group （P 〈 0. 05 ）, before chemotherapy, serum VEGF levels compared the control group and complete remission was significantly higher （P 〈 0. 05 ）, while the complete remission group and the control group, serum VEGF levels were not significantly different （P 〉 0. 05 ）, some of its recurrence in patients with recurrence of these changes. Conclusions The occurrence and development of acute leukemia and vascular endothelial growth factor levels are closely related.