关联保密法对结核病人HIV抗体检测的研究

Study of HIV screening from tuberculosis patients by correlation keeping secret method

目的探索结核病人群中HIV感染调查的方法，了解郑州地区结核病人群中HIV感染状况。方法采用连续抽样和关联保密法，对郑州地区7个结防机构2007年8月11日-11月31日就诊的活动性结核病人，用酶联免疫吸附试验（ELISA）进行HIV初筛，初筛阳性者做免疫印迹（WB）确认试验，并进行问卷调查。结果调查新登记结核病1583例，HIV阳性者9例，感染率0．57％；HIV感染病人年龄在13～60岁，男性组HIV感染率0．63％，女性组感染率为0．21％；不同年龄活动性结核病人中HIV感染者主要集中在青壮年，占88．9％；农村户口结核病人HIV感染率0．62％，城镇户口结核病人HIV感染率0．43％。固定人口HIV感染率0．67％，流动人口HIV感染率0．37％；HIV感染途径，采血浆、输入血液传播4例（44．4％），异性传播2例（22．2％）。结论关联保密法来调查结核病人群中HIV感染状况是可行的，郑州地区结核病人群中HIV感染率0．57％。

Objective To explore a methodology used for understanding the state of HIV infection in patients of tuberculosis in Zhengzhou city. Methods The primary screening of HIV infection was done by ELISA, and final screening of HIV infection was taken by WB. The subjests to be investigated were cases of tuberculosis. Results The rate of HIV infection was 0. 57% （9 cases ） in the 1583patients of tuberculosis. The rates of HIV infection was 0.63% and 0. 21% in male and females 13 60 years. Different age HIV/TB patients were mainly young men, accounts 88.9%. The rates of HIV infection was 0. 62% and 0.43 % in rural area and city, town registered TB patients. Fix population HIV infection rate 0. 67% , transient population HIV infection rate 0. 37%. The infection routes were transfusion 4 eases（44. 4% ） ,sex transmit 2eases（22. 2% ）. Conclusions Correlation to keep secret method is a feasible method that can be used to understand the state of HIV infection in patients of tuberculo- sis. The rate of HIV infection in patients of tuberculosis in Zhengzhou is 0. 57%.