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1-氨甲基-6,7-二甲氧基-1,2,3,4-四氢异喹啉盐酸盐的合成及表征 被引量：1

Synthesis and Characterization of 1-Aminomethyl-6,7-Dimethoxy-1,2,3,4-Tetrahydroisoquinoline Hydrochloride
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摘要 以3,4-二甲氧基苯乙胺为原料,经氯乙酰氯酰化得到N-氯乙酰基-3,4-二甲氧基苯乙胺,通过与邻苯二甲酰亚胺钾烃化,在P2O5的作用下经Bischler-Napieralski环合后,用水合肼肼解,硼氢化钾还原后与盐酸作用得1-氨甲基-6,7-二甲氧基-1,2,3,4-四氢异喹啉盐酸盐。产品结构经IR、1H NMR、MS确证。 1-aminomethyl-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride was synthesized from 3,4-dimethoxy-phenethylamin and chloroacetyl chloride via acylation,alkylation with phthalimide potassium,Bischler-Napieralski cyclization with the effect of P2O5,hydrazinolysis with hydrazine hydrate,reduction with potassium borohydride,reaction with HCl.The structures of target compound were characterized by IR,1H NMR and MS.
作者 程训官 夏铸 郑小红 余瑜
机构地区 重庆医科大学药学院
出处 《光谱实验室》 CAS CSCD 北大核心 2011年第5期2198-2201,共4页 Chinese Journal of Spectroscopy Laboratory
基金 国家自然科学基金资助项目(30772595 30171070和30371632) 重庆市科委攻关资助项目(20021425) 重庆市教委资助项目(20021804)
关键词 四氢异喹啉 环合 还原 结构表征 Tetrahydroisoquinoline Cyclization Reduction Structure Characterization
分类号 R914.5 [医药卫生—药物化学] O657.33 [理学—分析化学]
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参考文献9

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二级参考文献8

  • 1李桂珠,刘秀杰,王保杰,张立光,邵英禄.1-甲基-1,2,3,4-四氢异喹啉的简易合成[J].沈阳药科大学学报,2007,24(6):337-338. 被引量：5
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光谱实验室
2011年 第5期

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