摘要
目的观察不同月龄SAMP8鼠(快速老化鼠P8)血小板线粒体超微结构的变化。方法提取2、6及9月龄SAMP8鼠的血小板并进行电镜观察。结果随月龄的增加,SAMP8鼠血小板线粒体退变逐渐明显。9月龄SAMP8鼠的血小板线粒体呈明显的退行性变。结论 SAMP8鼠血小板线粒体超微结构呈增龄性改变,提示线粒体变性可能是SAMP8鼠快速老化的机制之一。血小板可广泛地用于研究线粒体机能和老化相关疾病。
Objective To observe the changes in the ultrastructure of platelets in different age groups of SAMP8 mice.Methods Mitochondria were isolated from platelets in 2,6 and 9 month-old SAMP8 mice and the ultrastructure of platelet mitochondria was observed using transmission electron microscopy.Results platelet mitochondria in SAMP8 mice displayed morphological abnormality,which exacerbated in extent with age.SAMP8 mice at 9 months of age showed obvious mitochondrial abnormality.Conclusion Mitochondrial degeneration might be one of the mechanisms leading to age-associated degeneration in SAMP mice at an early age and the platelets could serve as a biomarker for detection of mitochondrial function and age related disease.
出处
《解剖学研究》
CAS
2011年第4期262-264,共3页
Anatomy Research
