摘要
目的观察翠云草水提液对哮喘大鼠血清IgE、肺组织IL-5水平的影响。方法取雄性SD大鼠60只随机分为6组，以卵白蛋白（ova）致敏、激发的方法建立大鼠哮喘模型。用ELISA法测定各组大鼠血清IgE和肺组织IL-5的浓度。结果模型组IgE、IL-5的含量明显高于正常对照组（P〈0.01）；与模型组比较，翠云草水提液高剂量可下调血清IgE（P〈0．05）和肺组织IL-5水平（P〈0．01）。结论翠云草水提液能有效降低哮喘大鼠IgE和IL-5水平，进而可能抑制哮喘发作。
Objective To investigate effects of aqueous extract from Selaginella uncinata on the level of IgE in serum and IL-5 in lung of the asthmatic rats. Method Sixty male SD rats were randomly divided into six groups. Then the asthma rats model were made by ovalbumin （OVA）-sensitized and stimulated method. The level of IgE and IL-5 were detected by enzyme-linked immunosorbent assay （ELISA）. Result Compared with the normal control group, the levels of IgE and IL-5 in the asthmatic group were higher （P〈0.01）. The aqueous extract of Selaginella uncinata could decrease levels of IgE and IL-5. Conclusion The extract of Selaginella uncinata could effectively decrease IgE and IL-5 levels on asthma rats and improve the asthmatic symptoms.
出处
《实验动物与比较医学》
CAS
2011年第4期280-282,共3页
Laboratory Animal and Comparative Medicine
基金
浙江省中医药管理局项目（2007CA002）,浙江省卫生厅项目（2006A095）
