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阿尔茨海默病的主动免疫治疗策略与疫苗研发 被引量：3

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摘要 阿尔茨海默病（Alzheimer’s disease，AD）是引起痴呆的最常见疾病，以进行性记忆力和认知功能下降为主要临床表现。随着人口老龄化进程，该病引起越来越多的医学界及全社会的关注。众所周知，AD核心神经病理学改变包括细胞外β淀粉样蛋白（Aβ）沉积形成的老年斑以及细胞内由异常磷酸化tau蛋白聚合而成的神经原纤维缠结。
作者 王得新
机构地区 首都医科大学附属北京友谊医院神经内科
出处 《中华神经科杂志》 CAS CSCD 北大核心 2011年第9期587-589,共3页 Chinese Journal of Neurology
关键词 阿尔茨海默病 主动免疫治疗 疫苗研发 磷酸化TAU蛋白 神经原纤维缠结 神经病理学改变 认知功能下降 β淀粉样蛋白
分类号 R749.16 [医药卫生—神经病学与精神病学]
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参考文献24

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  • 2Wilcock DM, Gharkholonarehe N, Van Nostrand WE, et al. Amyloid reduction by amyloid-beta vaccination also reduces mouse tau pathology and protects from neuron loss in two mouse models of Alzheimer' s disease. J Neurosci, 2009, 29 : 7957-7965.
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同被引文献40

  • 1刘硕,胡雅儿,夏宗勤.小鼠脑内注射Aβ_(25-35)记忆和M受体变化及梓醇的调节作用[J].上海交通大学学报（医学版）,2007,27(8):945-948. 被引量：11
  • 2Fukami S, Watanabe K, lwata N, et al. Abeta-degrading endopeptidase, neprilysin, in mouse brain: synaptie and axonal localization inversely correlating with Abeta pathology. Neurosci Res, 2002, 43: 39-56.
  • 3Marr RA, Rockenstein E, Mukherjee A, et al. Neprilysin gene transfer reduces human amyloid pathology in transgenic mice. J Neurosci, 2003, 23 : 1992-1996.
  • 4Marr RA, Guan H, Rockenstein E, et al. Neprilysin regulates amyloid Beta peptide levels. J Mol Neurosci, 2004, 22 : 5-11.
  • 5Spencer B, Malt RA, Gindi R, et al. Peripheral delivery of a CNS targeted, metalo-protease reduces a β toxicity in a mouse model of Alzheimer' s disease. PIoS One, 2011. 6: el6575.
  • 6Hemming ML, Patterson M, Reske-Nielsen C, et al. Reducing amyloid plaque burden via ex vivo gene delivery of an Abeta- degrading protease: a novel therapeutic approach 1o Alzheimer disease. PloS Med, 2007, 4: 1405-1416.
  • 7Guan H, Liu Y, Daily A, et al. Peripherally expressed neprilysin reduces brain amyloid burden: a novel approach for treating Alzheimer' s disease. J Neurosei Res, 2009, 87: 1462-1473.
  • 8Park D, Joo SS, Kim TK. et al. Human neural slem cells overexpressing choline acetyhransferase restore cognitive function of kainic acid-induced learning and memory deficit animals. Cell Transplant, 2012, 21: 365-371.
  • 9Kanninen K, Heikkinen R, Maim T, el al. Intrahippocampal injection of a lentiviral vector expressing Nrf2 improves spatial learning in a mouse model of Alzheimer' s disease. Proc Nail Acad Sci U S A, 2009, 106: 16505-16510.
  • 10Lame ME, Chambers EE, Blamik M. Quantitation of amyloid beta peptides Aβ ( 1-38 ), Aβ ( 1-40 ), and Aβ ( 1-42 ) in humancerebrospinal fluid by ultra-performance liquid chromatography- tandem mass spectrometry. Anal Biochem, 2011,419: 133-139.

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中华神经科杂志
2011年 第9期

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