早期未治疗帕金森病患者情绪记忆损害的特点

Characteristics of emotional memory impairment in untreated patients with early Parkinson＇ s disease

目的探讨早期未治疗帕金森病（PD）患者情绪记忆损害的特点。方法利用标准的情绪图片（包括正性、负性和中性效价）对33例PD患者和31名年龄、性别和教育程度相匹配的健康对照组进行情绪记忆测试。结果与对照组[负性（13．4±1．4）分]相比，PD组[（8．9±1．0）分]负性情绪效价图片再认成绩差异有统计学意义（t=-14．87，P〈0．01）；PD组正性[（11．8±1．0）分]和中性[（7．9±1．4）分]情绪效价图片再认成绩与对照组[正性（12．4±2．2）分，中性（8．2±1．3）分]比，差异均无统计学意义。结论早期未治疗PD患者负性效价情绪记忆存在损害，而正性和中性效价情绪记忆相对保留。

Objective To characterize emotional memory impairment in untreated patients with Parkinson＇s disease （PD） in the early stages of the disease. Methods Emotional memory tasks using standardized sets of emotional pictures including positive, neutral and negative valence were tested in 33 untreated patients with PD in the early stages and 31 healthy controls matched with age, sex, and education. Results Compared with the healthy adults （ 13.4 ± 1.4 ）, PD patients had significant loss of negative valence picture memorizing （ 8.9 ± 1.0 ; t = - 14. 87, P 〈 0. 01 ）. There was no significant difference between PD patients and normal controls in positive （ 11.8 ± 1.0 vs 12.4 ± 2. 2 , t = - 0. 95 ） and neutral （7.9±1.4 vs 8.2 ± 1.3, t = -0.89） valence picture memorizing （both P〉0.05）. Conclusion The emotional memory for negative valence pictures is impaired but the emotional memory for positive and neutral is relatively spared in early PD patients without treatment.