612例美沙酮维持治疗门诊男性受治者性功能状况分析(英文)

Sexual function of 612 male addicts treated by methadone

目的:调查社区美沙酮维持治疗门诊男性病人性功能状况,分析其原因并探讨对策。方法:使用自制性功能状况调查表和勃起功能国际问卷-5对612名患者进行调查。结果:接受美沙酮维持治疗后性生活主观感受变差的患者要显著多于主观感受良好的患者(P<0.01),88.6%的患者不满意当前性生活状况,但90.7%的患者愿意继续接受美沙酮维持治疗;性欲低下患者和勃起功能障碍患者要多于接受治疗前(P<0.01);性功能正常患者和射精受抑患者要少于治疗前(P<0.01);勃起功能国际问卷-5评分与接受治疗时间无相关性,而与美沙酮维持剂量、患者年龄呈负相关。结论:美沙酮对男性性功能存在影响,适当的美沙酮维持剂量可以减少此类影响并提高治疗依从性。

Objective To determine sexual function in 612 male addicts with methadone maintenance therapy （MMT）,analyze its cause and explore the treatment strategies.Methods Self-made questionnaire and International Index of Erectile Function-5 （IIEF-5） were used in 612 male addicts receiving MMT.Results The number of addicts who felt worse sexual function was significantly more than those who felt better sexual function （P〈0.01）.About 88.6% addicts were dissatisfied with their current sexual function,90.7% of whom were willing to continuously receive MMT.The number of addicts suffering from hyposexuality and erectile dysfunction （ED） was significantly increased at post-MMT than at pre-MMT （P〈0.01）,while the number of addicts with normal sexuality and inhibitive ejaculation decreased significantly （P〈0.01）.Both the dose of methadone and the age of subjects were negatively correlated with IIEF-5 scores.Correlation between the duration of MMT and IIEF-5 scores was not found.Conclusion MMT might deteriorate sexual function in male addicts.To improve the compliance of MMT and sexual function in male addicts,the dose of methadone should be adjusted to minimally effective one.