分子印迹技术与固相微萃取技术联用的研究进展

THE DEVELOPMENT OF MOLECULARLY IMPRINTED TECHNIQUE COUPLED WITH SOLID PHASE MICROEXTRACTION

固相微萃取技术是一种广泛使用的样品前处理技术,涂层是固相微萃取技术的核心部分.目前商品化的涂层缺乏选择性,易受基质干扰,不适合复杂环境基质中痕量有机污染物的分析.分子印迹聚合物是一种具有强大分子识别功能的材料,具有高效的选择特异性,将其作为固相微萃取涂层,可提高其选择性,扩大其应用范围,是目前固相微萃取涂层的研究热点之一.本文介绍了分子印迹技术的基本原理,综述了近年来国内外分子印迹技术与固相微萃取技术联用的研究进展,包括分子印迹固相微萃取装置形式以及方法研究等,最后展望了分子印迹固相微萃取的发展方向.

Coating is considered to be the key element in solid phase microextraction（SPME） technique as it has been widely used in sample pretreatment.However,currently the commercially available fibers based on nonselective sorbent are lack of selectivity in the extraction and easy to be interfered by environmental matrix.Therefore,they are not suitable for the analysis of organic contaminants in complex environmental matrix.As a kind of material which have strong molecular recognition ability and high specific selectivity,molecularly imprinted polymers can greatly improve the separation capability of microextraction technique and expand the application scope of SPME when used as the coating materials of SPME,which has made it become one of research hotspots of SPME selective coatings.The concept,basic principle and method of molecularly imprinted technique,were introduced systematically,and the recent progress of molecularly imprinted technique coupled with solid phase microextraction,including the type of equipment of molecularly imprinted solid phase microextraction and the reaserch method,were also reviewed in this paper.Future research trends of molecularly imprinted solid phase microextraction（MISPME） were emphasized in the end of this paper.