盐酸吡格列酮对2型糖尿病合并高血压患者血压、血脂和内皮功能的影响

Effects of Pioglitazone hydrochloride on blood pressure,hyperlipemia and endothelia function in treatment of type 2 diabets with hypertension

目的探讨盐酸吡格列酮对2型糖尿病(DM)合并高血压患者血压、血脂和内皮功能的影响。方法采用随机、双盲、平行对照的临床研究方法,将64例应用磺酰脲类和双胍类治疗不佳的2型DM患者随机分为吡格列酮组(30mg/d)32例与对照组32例治疗,共24周。并于试验前后检测血压,空腹抽取静脉血检测血中血糖、血脂、一氧化氮(NO)、内皮素1(ET-1)的水平变化。结果经24周治疗后,治疗组的血压、三酸酰甘油(TG)、低密度脂蛋白(LDL-c)、ET-1水平与治疗前相比明显降低(P<0.05),高密度脂蛋白(HDL-c)、NO明显升高(P<0.05);组间比较有差异性(P<0.05)。结论对2型糖尿病合并高血压患者盐酸吡格列酮不仅能够降低血压、降低血脂,还能改善血管内皮功能。

Objective To evaluate the effects of Pioglitazone hydrochloride on blood pressure,hyperlipemia and endothelia function in the treatment of type 2 diabetes with hypertension.Methods Totally 64 patients were randomly and double-blindly divided into therapy group（n=32,pioglitazone hydrochloride 30mg,qd） and control group（n=32）,for 24 weeks.The blood pressure（BP）,TG,LDL-c,HDL-c,NO and ET-1 at the beginning and after 24 weeks of treatment were monitored respectively.Results The levels of BP,TG,LDL-c and ET-1 of therapy group decreased significantly（P〈0.05）;The levels of HDL-c and NO of therapy group raise significantly（P〈0.05）;There was significant difference between 2 groups（P〈0.05）.Conclusions Pioglitazone hydrochloride can obviously decrease the levels of BP and hyperlipemia,and can improve the endothelia function in the treatment of type 2 diabetes with hypertension.