产后骨关节炎患牛血液生化指标的研究

The Study of Hematological Biochemistry in Osteoarthritis Dairy Cow

通过对产后15～20d、跗关节炎患牛与正常奶牛血清中蛋白、甲状腺素(T3、T4)、维生素、葡萄糖、乳酸、丙酮酸、Ca、P等生化指标的比较,探讨血液生化指标的变化与奶牛骨关节疾病的关系。结果表明,试验组血清白蛋白显著低于对照组(P<0.05),而α-球蛋白显著高于对照组(P<0.05);试验组T3水平显著高于对照组(P<0.05),T4显著低于对照组(P<0.05);试验组乳酸和丙酮酸水平显著高于对照组(P<0.05);试验组血糖、VA、VC、VE及Ca、P含量均显著低于对照组(P<0.05),说明产后关节炎过程中T4、VA、VC的含量降低使关节软骨的胶原及蛋白多糖合成减少,解聚相对增多,引起血清蛋白组成发生变化;而产后血糖水平降低,引起乳酸、丙酮酸含量升高,低血糖又抑制了VC的合成;关节炎过程中可见Ca、P水平降低,可能是通过影响骨质代谢而促进了关节炎的发生。

This article contrasted albumin,thyroxine（T3,T4）,vitamin,glucose,lactic acid,pyruvic acid,Ca and P in the blood serum of the arthritis puerperium dairy cow,to study that the relation blood biochemical indicator＇s changes with Joint disease.The result indicated the albumin,T4,vitamin A,vitamin C,vitamin E,Ca and P were in experimental group notablely lower than control group,globulin-α,lactic acid,pyruvic acid and T3 were significant higher than control group.It showed that the content of T4 and vitamin were degraded in arthritis postpartum dairy cow maked the collagen in articular cartilage and proteoglycan reduce,depolymerization increase,to cause the compose of serum protein change;but blood sugar level depressed that it caused lactic acid and pyruvic acid raise,hypoglycemia inhibited composition of vitamin C,Ca and P level depressed.It maybe effect sclerotin metabolism to promote development of arthritis.