上皮—间质转化及其与头颈鳞状细胞癌的耐药性

Epithelial—mesenchymal transformation and association with chemoresistace in head and neck cancer

上皮—间质转化(EMT)是对上皮来源的细胞发生表型转化过程的概括,主要参与胚胎发育和肿瘤进展,并在化学治疗耐药中发挥重要的作用。耐药是肿瘤化学治疗不能取得治愈性疗效的重要原因之一,明确化学治疗耐药机制,对于准确预测肿瘤细胞对化学治疗药物的敏感性以及如何逆转耐药以保证化学治疗持续有效,从而提高临床疗效和患者的长期生存率具有十分重要的意义。本文就EMT及其生物学意义、肿瘤化学治疗的耐药机制、EMT与化学治疗耐药的关系、EMT与头颈鳞状细胞癌的化学治疗耐药性等研究进展作一综述。

The differentiated epithelial cells could be transformed into mesenchymal cells through a cellular program named epithelial—mesenchymal transformation（EMT）,which plays an important role in development,carcinoma invasion and also chemoresistance.Since chemoresistance always cause the failure of chemotherapy,to overcome chemoresistance is key to maintain the effectiveness of chemotherapy.This article reviews EMT and its biological significance,its association with chemoresistace,especially in head and neck cancer.