人抗原R在急性肺损伤中的研究

Role of human antigen R in acute lung injury

人抗原R（HuR）广泛分布于哺乳动物体内，主要分布于细胞核，在低氧、应激、紫外线等刺激下，可与多种富含Au序列的mRNA结合，增加了mRNA的稳定性。HuR可被p38MAPKMKZ、AMPK和PKC等多条信号通路调节，参与细胞周期、增殖、分化及炎症反应等。在肺的急性炎症反应中，HuR可以和多种炎症因子mRNA结合，如肿瘤坏死因子α、白介素19和白介素8等，影响了mRNA稳定性和蛋白表达。敲除HuR后，炎症因子的mRNA及蛋白表达量均明显减少，表明HuR在急性肺损伤中起了重要作用。

Human antigen R （HuR） is widely distributed in mammals, mainly in the nucleus. HuR can bind to AU-rieh elements-containing mRNAs under hypoxia, stress and ultraviolet ray stimulation, and increase the stability of target mRNAs, p38 MAPK MK2, AMPK and PKC are involved in regulating HuR, which plays an important role in cycle regulation, proliferation, differentiation and inflammation. In acute lung inflammation, HuR can bind to the mRNAs of tumor necrosis factor-s, interleukin-19 and interleukin-8 and affect the mRNA stability and the corresponding protein production. HuR knockdown reduces the levels of mRNA and protein expression of inflammatory factors, which shows that HuR plays an important role in acute lung injury.