毛细支气管炎患儿血清白细胞介素6、8和肿瘤坏死因子α水平检测的意义

Clinical significance of serum IL-6, IL-8 and TNF-ct in children with bronchiolitis

目的探讨毛细支气管炎患儿血清白细胞介素6（IL-6）、白细胞介素8（IL-8）和肿瘤坏死因子α（TNF-α）在毛细支气管炎患儿发病中的作用。方法收集50例毛细支气管炎患儿，检测其急性期与恢复期血清IL-6、IL-8和TNF-α水平，另选择20例健康儿童作为健康对照组进行比较。结果患儿在急性期血清IL-6、IL-8和TNF．口水平均明显高于恢复期和对照组（均P〈0．05），患儿恢复期血清IL-6、IL一8和TNF-α水平与对照组比较差异均无统计学意义（均P〉0．05）。结论血清IL-6、IL-8与TNF-α可能在毛细支气管炎发病过程中起重要作用，它们可能成为预测毛细支气管炎病情的重要指标。

Objective To explore the roles of IL-6, IL-8 and TNF-ct in infants with bronchiolitis. Methods The levels of serum IL-6,IL-8 and TNF-ct were detected in 50 infants with bronchiolitis during convales- cence stage and acute stage, and compared with those of 20 healthy children as control group. Results The serum levels of IL-6, IL-8 and TNF-ct during acute stage were significantly increased in comparison with those during conva- lescence stage（ all P 〈 0.05）, but there was no significant difference between convalescence stage and normal control group（all P〉0.05）. Conclusion The cytokines of IL-6,IL-8 and TNF-ot maybe play an important role in the pa- thogeny of bronchiolitis. The serum levels of IL-6, IL-8 and TNF-ot could be used to predict the degree of bronehiolitis in infants.