注射用磷酸肌酸钠中的微量钡含量测定研究

Rearch on Determination of Trace Barium in Creatine Phosphate Sodium for Injection

目的:建立石墨炉原子吸收法测定注射用磷酸肌酸钠中的微量钡。方法:以石墨炉法对注射用磷酸肌酸钠中微量钡进行测定。结果:方法回收率95.8%～98.8%,线性范围0.0～300μg.L-1,最低检测浓度为1μg.L-1,r=0.999 5,RSD<6.3%(n=6)。结论:本方法克服了钡的记忆效应,精密度好,线性范围宽,适用于石墨炉原子吸收法测定注射用磷酸肌酸钠中的钡。

Objective： To establish a method for determination of trace barium in Creatine Phosphate Sodium for Injection by graphite furnace. Methods：Trace barium in Creatine Phosphate Sodium for Injection was determined by graphite furnace atomic absorption spectrometry. Restilts：The recovery was from 95.8% to 98.8%. The calibration curve was linear in the range of 0. 0 -300 μg·L^-1 for barium with r = 0. 999 5, and the relative standard deviation was less than 6. 3% （ n = 6）. Conclusion： The method is linear wide- ly with good precision, and the interference of memory for barium is cecluded. It has been successfully applied to the determination of barium in creatine phosphate sodium for injection.