迁延性肺炎患儿血清免疫球蛋白、补体及T淋巴细胞亚群水平变化及意义

The serum immunoglobulin,complement and blood T lymphocyte level and significance in child with persis-tent pneumonia

目的探讨迁延性肺炎患儿血清免疫球蛋白、补体及T淋巴细胞亚群水平变化及临床意义。方法采用单向琼脂扩散法测定迁延性肺炎患儿（迁延性肺炎组，63例）、急性肺炎患儿（急性肺炎组，66例）及健康儿童（健康儿童组，70例）血清免疫球蛋白和补体水平，用直接免疫荧光法测定各组患儿血液T淋巴细胞亚群水平，观察三组血清IgA、IgG、Igbl、C3、C。及血液CD¨CD4、CD8、CD。／CD8水平。结果迁延性肺炎组：gG[（8．568±4．299）g／L]低于急性肺炎组[（10．867±3．012）g/L]和健康儿童组[（10．286±2．616）g／L]（F=3．86，P=0．0245）；迁延性肺炎组IgA[（0．941±0．336）g／L]低于急性肺炎组[（1．281±0．544）g／L,]和健康儿童组[（1．158±0．439）g／n]（F=4．57，P=0．0129）；三组间IgM、c3、c4、CD8、CD4／CD8水平差异均无统计学意义（均P〉0．05）；迁延性肺炎组CD，[（65．629±7．944）％]、CD。[（40．149±4．633）％]与急性肺炎组[（69．369±7．686）％、（43．099±5．262）％]与健康儿童组[（71．842±8．266）％、（44．281．4-4．749）％]差异有统计学意义（F=4．78、5．87，P=0．0107、P二0．0040）。急性肺炎组与健康儿童组间各项观察指标差异均无统计学意义（均P〉0．05）。结论迁延性肺炎患儿存在部分免疫功能低下及免疫功能紊乱。

Objective To study the serum immunoglobulin, complement and blood T lymphocyte level and clinical significance in child with persistent pneumonia. Methods The serum immunoglobulin and complement with persistent pneumonia group （63 cases）, acute pneumonia group （ 66 cases） and healthy child group （70 cases） were tested by single agar diffusion method respectively, and their blood T lymphocyte percentage were tested by direct im- munofluorescence method respectively. The three groups of serum immunoglobulin, complement and their blood T lym- phocyte level were analysed using these data. The measured data was analyzsed. Results The persistent pneumonia child group serum IgG[ （8. 568 ±4. 299） g/L] was lower than that in the acute pneumonia child group[ （ 10.867 ± 3.012） g/L ] and the healthy child group [ （ 10. 286 ± 2.616 ） g/L ] （ F = 3.86, P = 0.0245 ）. The persistent pneumoni- a child group serum IgA[ （0.941 ＋ 0. 336）g/L] was lower than that in the acute pneumonia child group[ （1. 281 ＋ 0.544） g/L] and the healthy child group [ （ 1. 158± 0.439） g/L] （ F = 4.57, P = 0.0129）. There were no differences among the three groups in the serum IgM, C3, C4 and the blood CDs, CDJCDs T lymphocyte percentage（ P 〉 0.05 ）. The persistent pneumonia child group blood CD3 （65. 629 ~ 7. 944）%, CD4 （40. 149± 4.633 ）% T lymphocyte per- centage had differences compared with those in the acute pneumonia child group [ （ 69. 369± 7. 686） %, （43. 099 ± 5. 262 ） % ] and the healthy child group [ （ 7 I. 842 ±8.266） %, （44.281± 4.749 ） % ] （ F = 4.78,5.87, P = 0~ 0107, P =0.0040）. There were no differences between the acute pneumonia child group and the healthy child group in the serum immunoglobulin, complement and the blood T lymphocyte percentage （P 〉 0.05）. Conclusion The persistent pneumonia child had partly low immune function and immune dysfunction.