心肌梗死溶栓危险积分与血浆脑钠肽水平相关性研究

Relationship of plasma brain natriuretic peptide with TIMI risk score in patients with acute myocardial in-farction

目的探讨急性心肌梗死（AMI）患者心肌梗死溶栓（TIMI）危险积分与血浆脑钠肽（BNP）水平的相关性。方法序列选择63例急性心肌梗死患者，以临床预测变量对其进行TIMI危险积分评分，酶联免疫吸附法检测患者血浆脑钠尿肽水平，分析其与TIMI危险积分不同层次之间的关系。结果63例患者中住院期间及随访期间的主要复合心血管事件发生者共9例，发生率14．3％。根据患者的危险积分，分析其与复合心血管事件发生率之间的关系，其复合心血管事件发生率随评分增加而呈进行性增高趋势（P〈0．05）；患者TIMI危险评分与其相应的BNP水平呈正相关（r=0．73，P〈0．05），随着TIMI危险积分的升高，BNP水平也逐渐升高。结论AMI患者TIMI危险评分与BNP水平正相关并与AMI预后有关，能够对AMI患者进行危险分层。

Objective To investigate the correlation of TIMI risk score and plasma brain natriuretic peptide （BNP） in patients with Acute myocardial infarction. Methods TIMI risk score were calculated in 63 patients with a- cute myocardial infarction;At the same time plasma brain natriuretic peptide were measured by enzyme-linked immune absorption assay（ELISA）. Analyze the correlation of TIMI risk score and plasma brain natriuretie peptide. Results Nine patients of 63 occurred cardiavascular events during hospitalization or follow-up（ 14.3% ）. The incidence of MACE in- creased significantly with the rise of TIMI risk score and BNP level. The TIMI risk score was positively correlated with the plasma BNP level（ r = 0.73, P 〈 0.05 ）. Conclusion The higher TIMI risk score and BNP level, the worse the prognosis,it could be use to predict the prognosis.