龙岩市2010年手足口病重症病例流行特征及高危因素研究

Study on epidemiological characteristics and risk factors of serious cases of hand-foot-mouth disease in Longyan in 2010

目的掌握手足口病重症病例的流行特征,分析普通病例转成重症病例的早期危险因素。方法采用病例对照研究,对2010年龙岩市手足口病重症病例进行流行特征及高危因素分析。结果重症病例以1-3岁为主,夏季多发;单因素分析：就诊不及时、神经系统症状、消化和呼吸系统症状,EV71阳性等为主要高危因素;多因素分析：神经系统症状、EV71阳性、家庭人口密集为高危因素。结论对早期出现神经系统症状、实验室检查EV71阳性、家庭人口密集的低年龄组手足口病患儿,应结合临床症状予以重点关注。

Objective To study the epidemiological characteristics of severe cases of hand-foot-mouth disease（HFMD）and analyze the risk factors for disease control and prevention. Methods The epidemiological characteristics and risk factors of severe cases of HFMD were investigated by using case-control study in Longyan in 2010. Results Aged 1-3 was main age group of severe cases. The cases occurred mainly in summer. The disease treatment not in time, neurological symptoms, gastrointestinal and respiratory symptoms, EV17 virus infection and so on were main risk factors by single factor analysis. And neurological symptoms, EVT1 virus infection and high density of family member were the risk factors by multiple factor logistic regression analysis. Conclusion Intensive care should be applied to the HFMD cases with neurological symptoms, EVT1 virus infection and high density of family member.