胰腺衍生因子与非酒精性脂肪性肝病
Pancreatic derived factor(PANDER) and non-alcoholic fatty liver disease (NAFLD)
摘要
非酒精性脂肪性肝病(NAFLD)是一种与全身糖脂代谢紊乱、心脑血管疾病、肝脏纤维化进展甚至肝脏肿瘤发生和发展密切相关的系统性疾病.在其发病过程中,糖脂代谢产物、细胞的氧化应激、非感染性免疫反应以及细胞的质膜系统稳态失衡起到重要作用。现有的假说在理解肝脏发生脂肪变之后的损伤过程方面已经有了比较深入的认识,
出处
《中华肝脏病杂志》
CAS
CSCD
北大核心
2011年第9期646-647,共2页
Chinese Journal of Hepatology
关键词
脂肪肝
胰腺衍生因子
胰岛素抵抗
高甘
油三酯血症
Fatty liver
Pancreatic derived factor
Insulin resistance
Hypertriglyceridemia
参考文献13
-
1Wong VW, Wong GL, Yip GW, et al. Coronary artery disease and cardiovascular outcomes in patients with non-alcoholic fatty liver disease. Gut, 2011, In press.
-
2Day CP. Non-alcoholic fatty liver disease: a massive problem. Clin Med, 2011, 11: 176-178.
-
3Wong VW, Wong GL, Tsang SW, et al. High prevalence of colorectal neoplasm in patients with non-alcoholic steatohepatitis. Gut, 2011, 60: 829-836.
-
4Soardo G, Donnini D, Domenis L, et al. Oxidative stress is activated by free fatty acids in cultured human hepatocytes. Metab Syndr Relat Disord, 2011, In press.
-
5Wang O, Cai K, Pang S, et al. Mechanisms of glucose-induced expression of pancreatic-derived factor in pancreatic beta-cells. Endocrinology, 2008, 149: 672-680.
-
6Cao X, Gao Z, Robert CE, et al. Pancreatic-derived factor (FAM3B), a novel islet cytokine, induces apoptosis of insulin-secreting beta- cells. Diabetes, 2003, 52: 2296-2303.
-
7Burkhardt BR, Yang MC, Robert CE, et al. Tissue-specific and glucose-responsive expression of the pancreatic derived factor (PANDER) promoter. Biochim Biophys Acta, 2005, 1730:215-225.
-
8Burkhardt BR, Greene SR, White P, et al. PANDER-induced cell- death genetic networks in islets reveal central role for caspase-3 and cyclin-dependent kinase inhibitor 1A (p21). Gene, 2006, 369: 134- 141.
-
9Cao X, Yang J, Burkhardt BR, et al. Effects of overexpression of pancreatic derived factor (FAM3B) in isolated mouse islets and insulin-secreting betaTC3 cells. Am J Physiol Endocrinol Metab, 2005, 289: E543-550.
-
10Burkhardt BR, Cook JR, Young RA, et al. PDX-1 interaction and regulation of the pancreatic derived factor (PANDER, FAM3B) promoter. Biochim Biophys Acta, 2008, 1779:645-651.
-
1李剑虹,王丽敏,李镒冲,毕宇芳,姜勇,米生权,戴蒙,徐瑜,宁光,赵文华.2010年我国成年人血脂异常流行特点[J].中华预防医学杂志,2012,46(5):414-418. 被引量:201
-
2杨帆,李良平.胰腺衍生因子与非酒精性脂肪性肝病的关系研究[J].国际消化病杂志,2012,32(6):334-336. 被引量:1
-
3杨帆,李良平.非酒精性脂肪性肝病患者血清和肝组织胰腺衍生因子水平变化及意义[J].实用肝脏病杂志,2014,17(5):479-483. 被引量:2
-
4徐象明.抗栓灵含片降高甘油三酯血症的临床疗效[J].中国生化药物杂志,1999,20(6):316-316.
-
5项靖楠,杨立勇.胰腺衍生因子的研究进展[J].国际内分泌代谢杂志,2011,31(3):177-179.
-
6庄峰,管庆波,高聆,于春晓,田利民,王静,范右飞,杜栋栋,赵家军.初诊2型糖尿病患者血清PANDER水平及其与胰岛β细胞功能的相关性[J].山东大学学报(医学版),2010,48(5):1-4. 被引量:1
-
7江太发.患了糖尿病 护肾很重要[J].山西老年,2010(9):56-56.
-
8邢建东,姚艳琴,薛文华.厄贝沙坦治疗早期糖尿病肾病临床疗效观察[J].山西医药杂志(上半月),2012,41(12):1252-1253. 被引量:6
-
9张君邦,妻烏昌平.非胰岛素依赖型糖尿病患者血清中甘油三酯浓度与高密度脂蛋白的关系[J].中国动脉硬化杂志,1995,3(3):236-236.
-
10李明,李倩.肝源性糖代谢稳态失衡178例临床分析[J].实用糖尿病杂志,2008,4(5):32-33. 被引量:3