比格犬垂体囊肿的组织形态学研究

Histological Observation on Spontaneous Hypophyseal Cyst in Beagle Dogs

目的研究比格犬垂体囊肿自发性病变的发生情况,以建立适用于GLP的实验动物背景资料。方法采用常规组织学方法,对60只8～10月龄实验对照组比格犬垂体进行组织病理学检查,光学显微镜下描述垂体囊肿的组织形态学特点并统计其发生率。结果囊肿多出现在垂体的远侧部,囊壁由一层扁平或立方状上皮构成,囊腔内可见黏液状物;囊肿总体发生率为23.3%,其中雌性为13.3%,雄性为33.3%。结论应加强比格犬自发病变的病理监测,为药物安全性评价提供实验动物的背景资料。

Objective To study the spontaneous occurrence of hypophyseal cyst in beagle dogs and establish the backgroud information of experimental animals for good laboratory practice（GLP）.Methods Sixty beagle dogs（male∶female=1∶1） aged 8-10 months were used in this study.The incidence of hypophyseal cyst was recorded and analyzed,and their histopathological features were examined by histopathology.Results Almost all the cysts were seen in the pars distalis hypophysis,and the wall was covered by a squamous or cuboidal epithelium.The total incidence rate of hypophyseal cyst was 23.3%.The incidence rate in females was 13.3% and in males was 33.3%.Conclusions It is suggested that spontaneous occurrence of hypophyseal cyst in Beagle dogs should be monitored so as to provide correct histopathological backgroud information of the dogs for drug safety evaluation.