急性脑梗死患者同型半胱氨酸与炎症因子的相关性分析

The correlation analysis between the homocysteine and the inflammatory factors in patients with acute cerebral infarction

目的研究急性脑梗死患者肿瘤坏死因子-α(TNF-α)及白介素-6(IL-6)与同型半胱氨酸(Hcy)之间的相关性,以探讨其与急性脑梗死发生的关系。方法收集158例急性脑梗死患者(ACI组)、122例健康人(对照组)血液标本,采用循环酶法检测血浆同型半胱氨酸(Hcy)水平,用ELISA法即酶联免疫吸附法测定血清肿瘤坏死因子-α(TNF-α),白介素-6(IL-6)水平。结果 ACI组Hcy、TNF-α和IL-6的水平均较对照组显著升高(P均<0.05)。ACI组Hcy与TNF-α、IL-6水平存在显著性正相关(r=0.346,P<0.05),TNF-α与IL-6水平之间也存在显著性正相关(r=0.382,P<0.05)。结论 Hcy、TNF-α、IL-6水平与急性脑梗死的发生密切相关,三者联合检测对急性脑梗死的预防、早期诊断及治疗和预后均有重要价值。

Objective To observe the correlation between the inflammatory factors and the hemocysteine（Hcy）,such as the tumor necrosis factor-α（TNF-α） ／／ the interleukin 6（IL-6）,in patients with acute cerebral infarction and to explore their relationships with the occurrence of acute cerebral infarction.Methods 158 cases of acute cerebral infarction（ACI group） and 122 healthy people＇s blood samples（control group） were collected.The level of plasma homocysteine（Hcy） was detected in the way of enzymatic cycling.The intensity of the tumor necrosis factor-α（TNF-α） and the interleukin 6（IL-6） was examined by using the method of ELISA（enzyme-linked immunosorbent assay）.Results By comparison,levels of Hcy,TNF-α and IL-6 in the ACI group were significantly higher than those in the control group（P0.05）.In the ACI group,there was a significant positive correlation between the Hcy and TNF-α and IL-6 levels（r=0.346,P0.05）,which can also be found between TNF-α and IL-6 levels（r=0.382,P0.05）.Conclusions Hcy,TNF-α and IL-6 levels and acute cerebral infarction are closely related.The joint detection of the three factors is of great importance in the prevention,early diagnosis,treatment and prognosis of the acute cerebral infarction.