二萜合酶的研究进展

Research advances of diterpene synthase

植物二萜类化合物广泛存在于自然界中,是一类重要的天然化合物。随着一些具有重要经济价值的二萜不断被发现,其生物合成中的二萜合酶也倍受关注。二萜合酶催化活性的多样性决定了终产物(二萜化合物)的丰富性。本文重点探讨了近年来二萜生物合成途径和二萜合酶的类型、克隆、催化机制及其合成生物学应用等研究进展。

Diterpenes,an important class of natural compounds,are widely distributed in nature.As the valuable diterpenoids continue to be found,diterpene synthase in the course of diterpene synthesis get as much attention as possible.The multiformity of end-product—diterpenoids were also due to the diversity of diterpene synthase.This paper focuses on the advances in recent biosynthesis pathway of diterpene and types,cloning,catalytic mechanism,synthetic biology application.