不同基因亚型乳腺癌组织中Duffy抗原趋化因子受体表达的研究

The Expression of the Duffy Antigen Receptor for Chemokines in Different Genotype Breast Cancer Tissues

目的：探讨不同基因亚型乳腺癌组织中Duffy抗原趋化因子受体（duffy antigen receptor for chemokines,DARC）的表达差异。方法：中国福利会国际和平妇幼保健院乳腺癌临床组织标本300例,患者年龄28~80（53.74±11.37）岁,通过免疫组织化学技术检测DARC、雌激素受体（estrogen receptor,ER）、孕激素受体（progesterone receptor,PR）、细胞角蛋白5（cytok-eratin5,CK5）、人表皮细胞生长因子受体（epidermal growth factor receptor,EGFR）、人表皮细胞生长因子受体2（epidermalgrowth factor receptor2,HER2）表达,并分析DARC在不同基因亚型乳腺癌组织中的表达差异。结果：38.60%基底细胞样乳腺癌组织中DARC呈高表达,46.15%HER2型乳腺癌组织中DARC呈高表达,76.92%腔内导管上皮A型乳腺癌组织中DARC呈高表达,55.68%腔内导管上皮B型乳腺癌组织中DARC呈高表达,63.16%类正常腺体型乳腺癌组织中DARC呈高表达。各组之间的DARC表达差异有统计学意义（P〈0.01）。结论：不同基因亚型乳腺癌组织中DARC表达有显著差异。

Objective：To analyze the expression of duffy antigen receptor for chemokines（DARC） in different breast cancer genotype.Methods： Human tissue sections were taken from 300 breast cancer patients,28-80（53.74±11.37） years old,DARC,estrogen receptor（ER）,progesterone receptor（PR）,cytokeratin 5,epidermal growth factor receptor（EGFR） and epidermal growth factor receptor 2（HER2） expression were examined by immunohistochemistry.Results： High expression of DARC immunostaining in different breast cancer genotype were basal-like subtype 38.60%,HER2 subtype 46.15%,luminal A subtype 76.92%,luminal B subtype 55.68%,normal breast-like subtype 63.16%,the difference was significant（P0.01）.Conclusions： DARC different expression in breast cancer genotypes is significant.