阻塞性睡眠呼吸暂停低通气综合征合并高血压患者血清白细胞介素-6和血管内皮生长因子水平的研究

The Study of Serum Interleukin-6 and Vascular Endothelial Growth Factor Level in Patients with Obstructive Sleep Apnea Hypopnea Syndrome Associated Hypertension

目的:探讨阻塞性睡眠呼吸暂停低通气综合征(obstructive sleep apnea hyponea syndrome,OSAHS)及OSAHS合并高血压(obstructive sleep apnea hyponea associated hypertension,OSAHAHT)患者血清白细胞介素-6(interleukin-6,IL-6)、血管内皮生长因子(vascular endothelial growth factor,VEGF)水平的变化及其临床意义。方法:选健康对照组30例、OSAHS30例,OSAHAST24例,用酶联免疫法(ELISA)测定血清VEGF、IL-6含量。所有患者采用多导睡眠图(polysomnography,PSG)监测。结果:(1)睡眠呼吸紊乱指数(apnea hypopnea index,AHI)、脉搏氧饱和度(SpO2)<90%时间占总睡眠时间的百分比(TST-SP<90%)OSAHAHT组较OSAHS组显著升高(P<0.01);平均血氧饱和度(MaO2)、最低血氧饱和度(LaO2)OSA-HAHT组较OSAHS组显著降低(P<0.05);2组间睡眠呼吸暂停最长时间(LAT)无显著差异;(2)血清IL-6、VEGF水平OSAHAHT组显著高于OSAHS组(P<0.01),2组与正常对照组均有显著差异(P<0.01);(3)血清IL-6、VEGF浓度均与AHI呈正相关,血清IL-6浓度还与TST-SP<90%呈正相关,血清VEGF浓度与MaO2呈负相关;(4)血清VEGF与IL-6水平呈正相关。结论:VEGF、IL-6可能共同参与了OSAHS的病理生理过程并促进高血压的发生、发展。

Objective：To investigate the role of interleukin-6（IL-6）,vascular endothelial growth factor（VEGF） in the pathogenesis of obstructive sleep apnea hyponea syndrome（OSAHS）and obstructive sleep apnea hyponea associated hypertension（OSAHAHT）.Methods：A total of 30 OSAHS cases,24 OSAHAHT cases and 30 healthy control cases were enrolled.The serum levels of IL-6 and VEGF were measured.Polysomnography（PSG） were used in all participants.Results：（1） Apnea hypopnea index（AHI） and TST-SP90% of patients with OSAHAHT were significantly higher than those with OSAHS,but MaO2、LaO2 were significantly lower.There were no significant difference between the two groups′LAT.（2） The serum levels of IL-6 and VEGF in patients with OSAHAHT were significantly higher than those of OSAHS cases.Compared with healthy control group,both the two groups had significant difference.（3） Both of the serum IL-6 and VEGF level were positively correlated with AHI.There was positive correlation between the serum IL-6 level and TST-SP90%,negative correlation between VEGF and MaO2.（4） There was positive correlation between the serum IL-6 and VEGF level.Conclusions： IL-6 and VEGF probably took part in the progress of OSAHS commonly and accelerated the occurrence and development of hypertension.