血清Ⅰ型前胶原氨基端前肽、Ⅰ型前胶原羧基端前肽、Ⅰ型胶原羧基端肽在骨转移性癌诊断中的应用

Diagnosic Clinical Value of Serum PINP,PICP and ICTP Contents in Cancer Patients with Bone Metastases

目的:探讨血清Ⅰ型前胶原氨基端前肽(PINP)、Ⅰ型前胶原羧基端前肽(PICP)、Ⅰ型胶原羧基端肽(ICTP)在骨转移癌诊断中的临床价值。方法:将80例肿瘤患者分为骨转移组41例和无骨转移组(对照组)39例,采用Soloway分级标准,将骨转移组患者再分为A、B、C3个亚组,所有患者空腹抽取静脉血。分析血清PINP、PICP、ICTP与骨转移程度之间的相关性及其彼此之间的相关性。结果:骨转移癌患者血清PINP、PICP、ICTP水平较对照组均升高,其中PICP、ICTP水平与对照组有显著差异(P<0.01);PINP、PICP、ICTP水平在A、B、C3组均依次递增;血清PICP水平与骨转移灶数目相关性良好(P<0.01),ICTP、PINP水平与骨转移灶数目呈一定相关(P<0.05);血清ICTP水平与PINP水平呈中度相关。结论:检测血清PINP、PICP、ICTP水平都能反映骨转移患者的病情变化,以检测血清PICP、ICTP水平临床价值高;血清PICP水平与骨转移数目的相关性良好。

Objective：To study the clinical value of determination of serum procollagen I N-terminal propeptide（PINP）,procollagen I carboxy-terminal propeptide（PICP） and carboxyterminal telopeptide of type I collagen（ICTP） contents in cancer patients with bone metastases for diagnosis.Methods： Serum PINP,PICP and ICTP contents were measured in 41 patients with bone metastases and 39 controls without bone metastases.The patients with bone metastases consisted of Group A,Group B and Group C.The comparison of bone turnovers among patients with different bone loads were analyzed.Results： Serum PICP,ICTP contents was significantly greater in patients with bone metastases than without bone metastases（P0.01）.With the increase of the extent of bone metastases,serum PINP,PICP and ICTP contents elevated.Levels of PICP correlated well to the number of foci（P0.01）,Levels of ICTP,PINP correlated to the number of foci（P0.05）.Levels of PINP correlated well to ICTP.Conclusions： The determinations of serum PINP,PICP and ICTP can reflect the clinical status of metastases size（PICP and ICTP more sensitive）;Levels of PICP correlat well to the number of foci.