生发中心B细胞发育和淋巴瘤发生的分子机制研究进展

Advances on molecular mechanism of B cell development related with lymphomagenesis in human germinal centres

生发中心是B细胞成熟和发育的场所，生发中心B细胞的活化和分化受复杂的内在信号和转录因子网络调控。正常情况下，这些转录因子之间的相互作用维持着生发中心内B细胞的动态稳定。当机体细胞遗传学发生改变、病毒感染等，多种转录因子的异常表达引起B细胞内在信号网络调节失去平衡，表现为B细胞增殖异常，凋亡、分化受阻。B细胞恶性肿瘤常与B细胞的遗传学改变及生发中心转录因子异常表达有关。

Germinal center is a site of B cell maturation and development, in which B cell activation and differentiation was regulated by inherent complexity signal＇and transcription factors networks. Under the normal condition, the interaction between these transcription factors maintain dynamic stability of B cell in germinal center. When cytogenetic abnormalities or viral infection appear, a varicty of abnormal expression of transcription factors induced the imbalance of B cell signal networks regulation, manifested as abnormal B cell proliferation, apoptosis, and differentiation was blocked. B cell malignancies were often associated with genetic change of B cell and abnormal expression of transcription factors.