100例早孕胚胎停育绒毛染色体核型分析

Analysis on chorionic villus karyotype for 100 cases of early embryo development arrest

目的:分析早孕胚胎停育与绒毛染色体异常的关系。方法:选择2010年～2011年3月安徽医科大学100例胚胎停育患者,对其进行绒毛染色体核型分析。结果:100例胚胎停育患者,孕周最长15周,最短6周。绒毛培养失败5例,培养成功率95.0%;检出异常核型34例,检出率35.8%,其中单纯染色体数目异常占55.9%,异常类型有:染色体数目异常23例,三倍体4例,四倍体1例,结构异常2例,嵌合体4例。95例早孕胚胎停育中,女性胚胎51例,占53.7%;男性胚胎44例,占46.3%。结论:胚胎染色体异常是胚胎停育的重要原因。

Objective：To investigate the relationship between early embryo development arrest and chorionic villus. Methods：100 chorionic villus specimens in our hospital from November,2010 to March,2011 were cultured for karyotype analysis. Results：Of the 100 cases,95 chorionic villus was successfully cultured（95%）,and abnormal embryo karyotypes were identified in 34 cases（35.8%）.The abnormal karyotypes include trisomy or monosomy,sex chromosome monosomy（23 cases）,triploid（4 cases）,tetraploid（1 case）,chromosomal abnormalstructures（2 cases）,mosaicism（4 cases）.Female embryos were 53.7%（51/95）,male embryos were 46.3%（44/95）. Conclusion：Embryo chromosomal abnormality is the most important reason of early embryo development arrest.