微生态制剂预防老年危重患者抗菌药相关性腹泻疗效观察

Clinical Observation of the Effect of Microecological Agents on the Prevention of Antibiotic Associated Diarrhea in CriticallyⅢElder Patients

目的:探讨微生态制剂对于老年危重患者抗菌药相关性腹泻的预防作用。方法:选择2004年12月～2008年12月应用抗菌药治疗的住院老年危重患者218例,根据抗感染治疗同时是否应用微生态制剂(金双歧)随机分为预防组(110例)和对照组(108例),观察两组抗菌药相关性腹泻(AAD)发生情况。结果:预防组AAD发生13例,发生率11.82%;对照组AAD发生36例,发生率33.33%,预防组AAD发生率明显低于对照组(P<0.01)。预防组AAD发生时间(7.65±2.80)d,病程(3.17±2.85)d,对照组AAD发生时间(5.50±2.47)d,病程(5.86±2.88)d。两组比较差异有统计学意义。结论:微生态制剂(金双歧)有助于防止老年危重患者AAD发生。

Objective：To investigate the preventive efficacy of microecological modular on antibiotic-associated diarrhea（AAD） in critically ill elder patients. Method：208 critically ill elder patients collected from Dec. 2004 to Dec. 2008 were divided into the prevention group （110） who received their anti -infection treatment, and the controlled group （108） who were given Golden Bifid or not. Their occurrence condition of diarrhea was compared. Result：AAD occurred to 13 of the 110 eider patients in prevention with the incidence of 11.28% while AAD occurred to 36 of the 108 elder patients in the controlled group with the incidence of 33.33 % （P 〈 0.01 ）. The mean duration of diarrhea was （7.65±2.80）d for the prevention group and （5.50±2.47）d for the controlled group. The disease courses of the two groups were respectively （3.17±2.85 ） d and （5.86±2.88 ） d. There were significant difference between the two groups in both indicators （ P 〈 0.01 ）. Conelusion：Microeeological modular （Golden Bifid） could be used to prevent AAD in critically ill elder patients effectively.