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脂联素基因多态性与移植后糖尿病的相关性研究 被引量：1

Correlation between Adiponectin Gene Polymorphism and Post-transplantation Diabetes Mellitus
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摘要 目的:探讨脂联素基因T45G多态性与移植后糖尿病的相关性。方法:398例肾移植术前无糖尿病史的患者,分为移植后糖尿病组(PTDM组,n=97)和非移植后糖尿病组(对照组,n=301),采用聚合酶链反应-限制性片断长度多态性(PCR-RFLP)技术,对脂联素基因T45G进行基因分型。结果:PTDM组患者GG基因型频率显著高于对照组(13.4%vs.4.6%,P=0.011),GG基因型患者移植术后发生PTDM的风险分别是TT和TG基因型的2.844和3.289倍(P<0.01)。结论:脂联素基因T45G的GG基因型是中国肾移植受者发生PTDM的危险因素。 Objective： To investigate the association between adiponectin gene polymorphism and the risk of post-transplantation diabetes mellitus （PTDM）. Method： A total of 398 unrelated renal allograft recipients without previously known diabetes （97 patients in with PTDM and 301 patients without PTDM） were genotyped for the presence of adiponectin gene variants （T45G） by PCR-RFLP assay. Result： GG genotype was more common in the patients with PTDM than those without PTDM （13.4% vs. 4. 6% ,P = 0. 011 ）. Compared with TT genotype and TG genotype, the risk of PTDM of GG genotype was 2. 844 and 3. 289 times, respectively （P 〈 0. 01 ）. Conclusion： These data suggest that GG genotype in T45G of adiponeetin gene is significantly associated with the increased risk of PTDM in Chinese renal allograft recipients.
作者 余爱荣 辛华雯 刘慧明 吴笑春 李高
机构地区 广州军区武汉总医院临床药理科 华中科技大学同济医学院药学院
出处 《中国药师》 CAS 2011年第9期1253-1255,共3页 China Pharmacist
关键词 移植后糖尿病 脂联素基因 肾移植受者 危险因素 Post-transplantation diabetes mellitus Adiponectin gene Renal allograft recipients Risk factor
分类号 R968 [医药卫生—药理学]
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参考文献10

  • 1Kasiske BL, Snyder JJ, Gilbertson D ,et al. Diabetes mellitus after kidney transplantation in the United States [ J ]. Am J Transplant,2003,3 (2) :178-185.
  • 2Montori VM, Basu A, Erwin PJ, et al. Posttransplantation diabetes : a systematic review of the literature [ J ]. Diabetes Care, 2002,25 ( 3 ) : 583-592.
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同被引文献22

  • 1余爱荣,辛华雯,吴笑春,李罄.含环孢素的三联免疫治疗方案对肾移植受者糖耐量的影响[J].药物流行病学杂志,2007,16(5):277-279. 被引量：8
  • 2Montori VM,Basu A,Erwin PJ. Posttransplantation diabetes:a systematic review of the literature[J].{H}DIABETES CARE,2002,(03):583-592.
  • 3Cosio FG,Pesavento TE,Kim S. Patient survival after renal transplantation:IV.Impact of post-transplant diabetes[J].{H}Kidney International,2002,(04):1440-1446.
  • 4Shah T,Kasravi A,Huang E. Risk factors for development of new-onset diabetes mel itus after kidney transplantation[J].{H}TRANSPLANTATION,2006,(12):1673-1676.
  • 5Hur KY,Kim MS,Kim YS. Risk factors associated with the onset and progression of posttransplantation diabetes in renal al ograft recipients[J].{H}DIABETES CARE,2007.609-615.
  • 6Baltar J,Ortega T,Ortega F. Posttransplantation diabetes mel itus:prevalence and risk factors[J].{H}TRANSPLANTATION PROCEEDINGS,2005,(09):3817-3818.
  • 7Heisel O,Heisel R,Balshaw R. New onset diabetes mel itus in patients receiving calcineurin inhibitors:a systematic review and meta-analysis[J].{H}AMERICAN JOURNAL OF TRANSPLANTATION,2004.583-595.
  • 8Sumrani N,Delaney V,Ding Z. Posttransplant diabetes mel itus in cyclosporine-treated renal transplant recipients[J].{H}TRANSPLANTATION PROCEEDINGS,1991.1249-1250.
  • 9Numakura K,Satoh S,Tsuchiya N. Clinical and genetic risk factors for posttransplant diabetes mel itus in adult renal transplant recipients treated with tacrolimus[J].{H}TRANSPLANTATION,2005.1419-1424.
  • 10Chimienti F,Devergnas S,Favier A. Identification and cloning of a beta-cellspecific zinc transporter,ZnT-8,localized in to insulin secretory granules[J].{H}DIABETES,2004.2330-2337.

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中国药师
2011年 第9期

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