摘要
目的:探讨菌毒清颗粒的镇痛、抗炎作用。方法:采用醋酸扭体、热板法观察菌毒清的镇痛作用,采用毛细血管通透性及耳廓肿胀实验研究其抗炎作用。结果:菌毒清低、中、高剂量组小鼠出现扭体反应的次数均明显减少(P<0.01);菌毒清中、高剂量组均能降低小鼠腹腔毛细血管通透性(P<0.05或0.01);菌毒清中、高剂量组均能减轻小鼠耳廓肿胀度(P<0.01);但对热板至痛小鼠无明显影响。结论:菌毒清具有明显的镇痛抗炎作用。
Objective： To study the analgesic and anti-inflammatory effects of Junduqing granule in mice. Method ： The analgesic effect of Junduqing granule was observed by acetic acid-induced writhing and hot-plate test, and the anti-inflammatory effect was observed by the tests of ear swelling caused by xylene and capillary permeability. Result： Junduqing granule could obviously decrease the number of writhing, inhibit auricle swelling and restrain capillary permeability without obvious effect on the pain threshold in the hotplate test. Conclusion： Junduqing granule has obviously analgesic and anti-inflammatory effects.
出处
《中国药师》
CAS
2011年第9期1278-1280,共3页
China Pharmacist
基金
广东省中医药强省课题(编号:2010337)
关键词
菌毒清颗粒
镇痛
抗炎
Junduqing granule
Analgesic
Anti-inflammatory
