五苓散对代谢综合征患者瘦素、脂联素等的影响

Effects of Wuling Powder on Adiponectin and Leptin in the Patients with Metabolic Syndrome

目的:观察五苓散对代谢综合征(MS)患者脂肪细胞因子瘦素(LEP)、脂联素(APN)等的影响。方法:64例患者随机分为观察组(五苓散)及对照组(基础治疗),比较用药前、用药12周患者的LEP、APN、超敏C反应蛋白(hs-CRP)、腰围、体质量、空腹血糖(FPG)、血脂等指标。结果:两组治疗后LEP、体质量、腰围、hs-CRP、三酰甘油(TG)、FPG均明显降低,APN、高密度脂蛋白(HDL-c)明显增高(P<0.01或0.05)。治疗后两组间LEP、APN、体质量、腰围、FPG等均差异显著(P<0.01),腰围变化与APN呈负相关性,r=-0.244(P<0.01);而hs-CRP及血脂差异无统计学意义结论:经方五苓散可有效改善代谢综合征患者的临床体征、血糖水平,能明显改善瘦素抵抗、低脂联素水平。

Objective： To study the efficacy of Wuling powder in the treatment of metabolic syndrome and effects on adiponectin and leptin. Method： 64 patients were randomly divided into test group （treated by Wuling powder） and control group （treated by basic therapy ）. The indicators including leptin, adiponectin, hs-CRP, weight ,waist line, FPG, Hbal c and lipid were compared before and after 12 weeks of the treatment. Result： The two groups both showed significant decrease of leptin, hs-CRP,weight, waist line, FPG and TG, while significant increase of HDL-c and adiponectin （P 〈 0. 01 or P 〈 0. 05 ）. There were notable differences in leptin, adiponectin, weight,waist line and FPG between the two groups （P 〈 0. 01 ） while Hs-CRP and lipid had no statistical differences. The change of waist line showed negative correlation with adiponectin with the correlation coefficient of-0. 244 （P 〈 0. 01 ）. Conclusion： Wuling powder can improve clinical signs and disorder of glucose in the patients with metabolic syndrome by significantly affecting the levels of leptin and adiponectin.