摘要
目的:考察柔红霉素和胰岛素配伍在葡萄糖溶液中的稳定性。方法:观察及测定柔红霉素-胰岛素-5%葡萄糖配伍后分别在室温避光和室温不避光条件下放置24 h内外观、pH变化及不溶性微粒,采用高效液相色谱法测定配伍液中柔红霉素、胰岛素含量的变化。结果:配伍液在24 h内无浑浊、沉淀、气体产生,颜色、pH、不溶性微粒数等无明显变化,柔红霉素、胰岛素含量无明显变化。结论:在试验条件下,柔红霉素、胰岛素在5%的葡萄糖注射液中配伍稳定。
Objective: To observe the compatibility of insulin and daunorubicin for injection. Method: The changes in appearance, particles and pH of the mixture in 5% glucose injection within 24 h at ambient temperature with of without hight were observed. The concentrations of insulin and daunorubicin were determined by HPLC. Result: There was no evident changes in appearance and color without gas, precipitation or turbid generated. Also there was no changes in insoluble particles, pH and the content of insulin and daunorubicin within 24 h. Conclusion: Insulin mixing with daunorubicin in 5% GS injection is stable within 24 h.
出处
《中国药师》
CAS
2011年第9期1359-1360,共2页
China Pharmacist