铜绿假单胞菌的耐药性研究

Study on the resistance of Pseudomonas aeruginosa

目的通过了解铜绿假单胞菌的临床标本的来源种类、患者的年龄、临床科室的分布和耐药性,为临床合理用药提供参考。方法采用VITEK32系统鉴定细菌,K-B法做体外药敏试验。结果共分离出270株铜绿假单胞菌,主要来源为痰液标本(占87.78%);感染者以中老年人为主,标本主要来自危重医学科和神经外科;铜绿假单胞菌对亚胺培南和美罗培南的敏感率最高,其他大多数抗生素均表现出较高的耐药率。结论铜绿假单胞菌主要引起呼吸道感染,其多重耐药趋势明显,耐药情况严重。

Objective To understand clinical sources,The age of patients,distribution of clinical departments,resistance of Pseudomonas aeruginosaandprovide evidence for clinical use of drug.MethodsBacteria wereidentified by VITEK32 system,K-B method method used in antibiotics susceptibility test.Results270 Pseudomonas aeruginosa strains were separatedand mainly from the sputum（accounting 87.78%）;the elderlywere mainlyinfected person;Specimens mainly come from the Critical Care Medicine Branch and the Department of Neurosurgeryand hadthe highest sensitive rate to Imipenem and Meropenem,Most other antibiotics hadshown a higher rate of drug resistance.Conclusions Pseudomonas aeruginosa mainly causes infection ofrespiratory tract,its multidrug resistant trend is obvious and severely resistant to antibiotics.