吸烟对糖尿病进程的影响

The Impact of Smoking on Diabetes Process

大量的研究结果显示吸烟是糖尿病发生发展的主要危险因素之一。烟草中的尼古丁可以直接损害胰岛β细胞,影响胰岛素信号转导以及炎性因子表达异常引起胰岛素抵抗,进而引发一系列糖脂代谢紊乱。吸烟加速糖尿病慢性并发症的进程,增加糖尿病大血管和微血管病变。虽然长期戒烟带来的益处超过了短期体质量改变的危害,但戒烟问题仍不容乐观,戒烟药物的有效或安全性缺乏足够的证据,糖尿病患者戒烟的课题需要进一步研究。

Numerous studies showed that smoking is a major diabetes risk factor.Nicotine in tobacco can damage β-cell,affect insulin signal transduction and inflammatory cytokine expression caused by abnormal insulin resistance,triggering a series of lipid disorders.Smoking speed up the process of chronic complications of diabetes,increased macrovascular and microvascular disease.Although the long-term benefits of quitting smoking and body mass change over the short-term harm,but the problem is still not optimistic,smoking cessation drugs effective or sufficient evidence of the lack of security,the subject of smoking cessation in patients with diabetes requires further study.