白细胞介素8、白细胞介素10、C反应蛋白与糖尿病肾病的相关性研究

The Correlation Study of Cytokines IL-8,IL-10 and C-reactive Protein and Diabetic Nephropathy

目的探讨白细胞介素8(IL-8)、IL-10、C反应蛋白(CRP)在糖尿病肾病患者中的变化。方法将171例糖尿患者根据1999年WHO的糖尿病诊断标准及糖尿病肾病的诊断标准分为两组:糖尿病并发糖尿病肾病组(85例)、糖尿病无糖尿病肾病组(86例),另选90例健康体检人员作为对照组。所有受检者血清IL-8I、L-10采用放射免疫分析方法检测,CRP采用酶联免疫分析方法检测。结果糖尿病肾病组患者血清中IL-8、CRP明显高于糖尿病无肾病组和健康对照组,差异有统计学意义(P<0.05);糖尿病肾病组患者血清中IL-10水平低于糖尿病无肾病组,与健康对照组水平接近。结论 IL-8I、L-10、CRP与糖尿病肾病的发生发展相关,促进炎性反应的细胞因子IL-8、CRP和抑制炎性反应的细胞因子IL-10在糖尿病肾病发展过程中起着不同作用。

Objective ITo investigate IL-8,IL-10 and C-reactive protein levels in the different stages of diabetic nephropathy.Methods By the standard of diabetic diagnosis with WHO in 1999 and the standard of Diabetic nephropathy,all the 171 diabetic patients were divided into two groups：diabetic nephropathy group（85 cases）,patients without diabetic nephropathy（86 cases）.90 healthy people were selected as the control group.For all subjects the following indices were measured including IL-8 and IL-10 levels with radiometricimmuno assay and C-reactive protein with enzyme immunoassay.Results The results showed that in patients with diabetic nephropathy IL-8 and CRP were higher than the diabetic patients without nephropathy group and the control group,the difference was significant（P〈0.05）.It is noteworthy that the content of IL-10,in patients with diabetic nephropathy,was lower than the diabetic patients without nephropathy group,and the control group similar.Conclusion IL-8,IL-10 and C-reactive protein content in serum are related to the development of diabetic nephropathy,IL-8,C-reactive protein are cytokines which accelerate inflammatory.IL-10 is a cytokine which suppresses inflammatory.They have different roles in diabetic nephropathy.