摘要
以氯甲基三甲基硅烷、苄胺、丙烯酸甲酯为起始原料,经过取代、甲氧甲基化、合环,最后脱保护,得到标题化合物,总收率为86.1%。由核磁共振氢谱对产物进行了结构表征。本方法具有反应条件温和、产率高、易于纯化的特点,为目标化合物的合成提供了新途径。
The titled compound was synthesized by using(chloromethyl)trimethylsilane,benzylamine and methyl acrylate as starting material via substitution,methoxy-methylation,cyclization and deprotection,the total yield was 86.1%.The produets were charaeterized by using 1H NMR.The synthetic route exhibites the advantages such as mild conditions,high yield and easy purification.
出处
《化学通报》
CAS
CSCD
北大核心
2011年第9期850-852,共3页
Chemistry