同型半胱氨酸与心力衰竭

Homocysteine and Heart Failure

研究表明，同型半胱氨酸水平升高是心血管疾病的独立危险因素，是心肌梗死进展到慢性心力衰竭的重要因素。血浆同型半胱氨酸的水平与B型脑钠肽呈正相关，血管周围和间质的胶原堆积引起心肌重塑，机制可能与同型半胱氨酸直接或间接作用于心肌有关。而小剂量服用维生素降低血浆中同型半胱氨酸水平可以提高治疗慢性心衰的疗效。因此，同型半胱氨酸可能是潜在的慢性心力衰竭的病因，需要进一步探索同型半胱氨酸在慢性心力衰竭的作用机制，以及进一步研究证实补充维生素B降低血浆同型半胱氨酸的含量是否可以提高慢性心力衰竭患者临床预后。

Hyper - homocysteinemia （HHCY） is an indipendent risk factor of cardiovascular disease and it is also an important factor of the development of congestive heart failure i CHF）. The plasma homocysteine levels is positively correlated with B brain sodi- um peptide （NBP）. Cardiac remodeling is caused by accumulation of interstitial and perivascular collagen. The mechanism is that the homoeystein has direct or indirect function in the cardiac muscle. The small dosage of the nutrient can reduce the plasma homocys- teine level in order to enhance therapeutic effect of CHF. In conclusion, HHCY may be a potential etiological factor of CHF. Future studies are needed to explore the mechanisms of HHCY in CHF. Supplement Vitamin B can reduce the plasma homocysteine levels. Whether it can enhance clinical prognosis of CHF should be studied furtherly.