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艾司西酞普兰在治疗抑郁症中的应用 被引量：5

Escitalopram Treatment in the Patients with Depressive Disorder
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摘要 艾司西酞普兰结合高亲和力和低亲和力两种蛋白位点，故起效比其它选择性5-羟色胺回收抑制剂为快，效果优于西酞普兰和帕罗西汀，与舍曲林、文拉法辛和安非他酮效果相似，本文对艾司西酞普兰在治疗抑郁症中的作用作一综述。 Because Escitalopram has two albumin binding sites it has favorable shortterm outcomes compared with Paroxetine and Citalopram. The therapeutic efficacy of Escitalopram is similar to the efficacy of Sertraline and Bupropion. The initial dose and the largest dose of Escitalopram are 10mg/d and 20mg/d respectively.
作者 喻东山
机构地区 南京医科大学附属脑科医院
出处 《国际老年医学杂志》 2011年第5期222-225,共4页 International Journal of Geriatrics
关键词 艾司西酞普兰 抑郁症 药动学 药物相互作用 Escilalopram Depression Pharmacokinetics Drug Interactions
分类号 R971.43 [医药卫生—药品]
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参考文献10

  • 1Murdoch D, Keam SJ. Escitalopram: a review of its use in the management of majir depressive disorder [J]. Drugs, 2005, 65 (16): 2379-2404.
  • 2Hoschl C, Svestka J. Escitalopram for the treatment of major depression and anxiety disorders [ J ]. Expert Rev Neurotherapeutics, 2008, 8 (4): 537-552.
  • 3Safarinejad MR. Safety and efficacy of escitalopram in the treatment of premature ejaculation: a double - blind, placebo- controlled, fixed- dose, randomized study[J]. J Clin Psyehopharmacol, 2007, 27:444 - 450.
  • 4Goodman WK, Bose A, Wang Q. Treatment of gener- alized anxiety disorder with escitalopram: pooled resuhs from double - blind, placebo - controlled trials [ J]. J Affect Dis, 2005, 87: 161 -167.
  • 5Hirschfeld RA, Vornik I+A. Newer antidepressants: review of efficacy and safety of escitalopram and dulox- etine [Jl. J Clin Psychiatry, 2004, 65 [ Suppl 4] : 46 - 52.
  • 6Doerr JP, Spiegelhalder K, Petzold F, et al. Impact of escitalopram on nocturnal sleep, day -time sleepi- ness and performance compared to amitriptyliue: a ran- domized, double - blind, placebo - controlled study in healthy male subjects [ J ]. Pharmacopsychiatry, 2010, 43: 166-173.
  • 7Baldwin DS, Stein DJ, Dolberg OT, et al. How long should a trial of eseitalopram treatment be in patients with major depressive disorder, generalized anxiety dis- order or social anxiety disorder? An exploration of the randomized controlled trial database [ J]. Hum Psycho- pharmaeol Clin Exp, 2009, 24:269-275.
  • 8Leuchter AF, Lesser IM, Trivedi MH, et al. An open pilot stydy of the combination of escitalopram and bupro- pion -SR for outpatients with major depressive disorder [J]. J Pstchiatric Practice, 2008, 14 (5): 271 - 280.
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国际老年医学杂志
2011年 第5期

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