包覆甲氧基肉桂酸辛酯固体脂质微粒的制备及性能

Preparation and characterization of solid lipid nanoparticles loaded octyl methoxycinnamate

引言固体纳米脂质微粒是20世纪90年代初新开发的一种活性组分载体，主要是利用固体油脂在冷却或相分离过程中固化、结晶形成固态结构，活性组分则被包覆在脂质结构中[1]。包覆活性组分的固体脂质微粒与皮肤角质层有很好的亲和性，能有效地将活性组分输送并渗透进角质层，使得活性组分有效地作用于皮肤的深层细胞；粒径小于400nm的纳米脂质载体在皮肤上可以形成很好的闭合体系，可增强皮肤的水合作用，应用于各种护肤产品中可提高产品的保湿性能；活性组分嵌于纳米脂质载体微孔结构中后，可降低活性组分的化学降解性能从而增强其稳定性口[1-4]。

Preparation and properties of solid lipid nanoparticles carried octyl methoxycinnamate （OMC） were studied. The influence of octyl methoxycinnamate （OMC） and pH value on the distribution, size, Zeta potential of solid lipid nanoparticle were studied. Meanwhile the configuration, particle size, composition and sunscreen properties were characterized. The result showed that the Zeta potential of solid lipid nanoparticle was about 40 mV with optimizing composition and middle or weak basic pH condition. The average particle size of solid lipid nanoparticle was about 150 nm and the particle distribution was homogeneous. Particle configuration was spherical with or without OMC and little flocculation. Carried OMC increased the particle size. OMC with lipid material, emulsifier formed the solid lipid nanoparticle together but not carried in the core. The solid lipid nanoparticle with OMC have good ultraviolet adsorption and the synergy function was between the solid lipid nanoparticles and sunscreen.