摘要
为了发现高效、低毒的农药先导化合物,以真菌几丁质为研究对象,以取代苯甲酸、5-取代苯基-2-呋喃甲醇为起始原料,设计合成了23个新型取代苯甲酰胺基硫代甲酸-(5-取代苯基-2-呋喃)-甲酯,其结构经IR,1H NMR和元素分析确证.初步生测结果表明,在50μg/mL浓度下,化合物对黄瓜褐斑菌、黄瓜灰霉菌、黄瓜枯萎菌表现出明显的防效,尤其对于黄瓜灰霉菌,大部分化合物的防效优于对照药剂40%菌核净WP.
To find new pesticide lead compounds with high activity and low toxicity,chitin was chosen as the research target.23 novel aryl thiocarbamic acid-5-aryl-2-furanmethyl esters were designed and synthe-sized from substituted benzoic acid and 5-aryl-2-furanmethanol.Their structures were confirmed by IR,1H NMR and elemental analysis.The preliminary bioassay results indicated that some compounds showed obvious inhibition effects against Corynespora cassiicola,Botrytis cinereapers,Fusarium oxysporum,especially to Botrytis cinereapers in which most compounds showed higher inhibitory rate than control fungicide 40% WP dimethachlon.
出处
《有机化学》
SCIE
CAS
CSCD
北大核心
2011年第9期1411-1418,共8页
Chinese Journal of Organic Chemistry
基金
国家973计划(No.2010CB126104)
国家自然科学基金(No.20872175)
农业部农药化学与应用重点开放实验室课题(No.MOAPCA201010)
绿色农药与生物工程教育部重点实验室开放课题(No.2008GDGP0101)资助项目