手性咪唑啉酮离子液体的合成

Synthesis of Chiral Imidazolinone-Based Ionic Liquids

手性离子液体在不对称合成中作为手性诱导物具有广泛的应用前景.手性咪唑啉酮类催化剂是有机胺催化剂中重要的一种类型,是不对称有机催化领域研究的热点之一.从绿色化、经济化的角度出发,以天然手性源物质L-酪氨酸为起始原料,经过酯化、胺解、关环、[3+2]环加成等多步反应合成了7种未见文献报道的手性咪唑啉酮类离子液体,并通过1H NMR,13C NMR,ESI-MS,[α]D20,DSC,TGA等方法对其结构及性质进行了表征.

The chiral ionic liquids have broad applications as inducers for asymmetric reactions. Chiralimidazolidinones are important sorts of aminocatalysts, which have been attracted much attention in research of enantioselective organocatalysis field. From the view of greening and economization, 7 new chiralimidazo l idincrne ionic liquids with different anions are synthesized from L-tyrosine, which is a kind of natural chiral materials, through esterfication, amination, cyclization, [3＋2] cycloaddition, etc. The structuresand properities were characterized by 1H NMR, 13C NMR, ESI-MS, IR, [α]D20, DSC and TGA methods.