水介质中Yb(OTf)_3催化下喹唑啉酮衍生物的绿色合成

A Clean Synthesis of Quinazolinone Derivatives in Water Catalyzed by Yb(OTf)_3

在水介质中,醛或酮首先和邻氨基苯甲酰肼反应形成腙;在1 mol%Yb(OTf)3催化下,再与另外一分子醛或酮反应,构建一系列不同取代的喹唑啉酮衍生物.该方法具有中性反应条件、产率高(80%～94%)、操作简单和环境友好等优点.产物的结构通过IR,1H NMR和HRMS表征.

Using water as a green reaction media,aldehydes or ketones react with 2-aminobenzohydrazide to give hydrazone firstly,and then a series of quinazolinone derivatives are obtained by the reaction of the hydrazone with another molecule of aldehyde or ketone catalyzed by 1 mol% Yb（OTf）3.This method provides several advantages such as neutral conditions,high yields（80%～94%）,simple work-up and environmental benignity.The structures were established by spectroscopic data of IR,1H NMR and HRMS techniques.