西非产阔叶乌檀中三萜和甾醇类成分的研究

Triterpenes and sterols from Nauclea latifolia

目的:研究非洲民间药物——茜草科植物阔叶乌檀Nauclea latifolia Smith的化学成分。方法:采用硅胶、Sepha-dex LH-20柱色谱等方法分离化合物,根据波谱数据和理化常数确定其结构。结果:从阔叶乌檀甲醇提取物中分离得到12个非生物碱类化合物,其中8个为三萜及其皂苷类,即24-烯-环阿尔廷酮(1),熊果醛(2),奎诺酸(3),铁冬青酸(4),3β,19α,23,24-四羟基乌苏烷三萜(5),pyrocincholic acid 3β-O-β-D-fucopyranoside(6),quinovic acid 3β-O-β-D-glucopyranoside(7),quinovicacid-3β-O-D-glucopyranosyl-(28→1)-β-D-glucopyranosyl ester(8);甾醇类4个,即β-谷甾醇(9),豆甾-3,6-二酮(10),豆甾-4-烯-6β-醇-3-酮(11),胡萝卜苷(12)。结论:除化合物4,9,12外,所有化合物均首次从该植物中分离得到,其中化合物2,6,10,11为首次从乌檀属中分离得到。

Objective：To investigate the chemical constituents of Nauclea latifolia,which is an African folk medicine and collected from Guinea.Method： The chemical constituents were isolated by silica gel and Sephadex LH-20 column chromatographies,and structurally elucidated by spectral evidence together with physiochemical properties.Result：Twelve compounds including 8 triterpenes and 4 sterols were isolated from the roots of N.latifolia,and their structures were defined as 24-en-cycloartenone（1）,ursolic aldehyde（2）,quinovic acid（3）,rotundic acid（4）,3β,19α,23,24-tetrahydroxyurs-12-en-28-oic acid（5）,pyrocincholic acid 3β-O-β-D-fucopyranoside（6）,quinovic acid 3β-O-β-D-glucopyranoside（7）,quinovic acid-3b-O-D-glucopyranosyl-（28→1）-β-D-glucopyranosyl ester（8）,β-sitosterol（9）,stigmastan-3,6-dione（10）,stigmast-4-en-6β-ol-3-one（11）and daucosterol（12）.Conclusion： All compounds except for 4,9,and12 are isolated from this plant for the fist time,while compounds 2,6,10,and 11are isolated from the genus Nauclea for the first time.