甲基强的松龙两种不同用法在成人哮喘重度持续发作中的疗效比较

Effective comparison of two different usages of methylprednisolone in treating severe persistent attack of adult asthma

目的:比较甲基强的松龙两种用法在成人哮喘重度持续发作中的治疗效果。方法:将2010年1月～12月在我院就诊的成人哮喘重度持续发作的患者80例随机分为两组,每组各40例,治疗组采用负荷量(80 mg/8 h)为起始治疗量,对照组采用常规治疗量(40 mg/8 h)为起始治疗量,逐步增加至负荷量。结果:治疗组平均缓解时间为(16±3.5)h,对照组为(27±4.7)h,两组比较差异有统计学意义(P<0.05)。结论:以负荷量为起始治疗量有助于成人哮喘持续发作的快速缓解。

Objective：To compare the curative effect of two usages of methylprednisolone in severe persistent attack in adult asthma.Methods：80 patients with severe persistent attack of adult asthma were randomly divided into 2 groups（A and B）,40 cases in each group.The treatment group used the load dosage 80mg/8h as the initial treatment dose of methylprednisolone.The control group received the conventional treatment dosage 40mg/8h as the initial treatment dose and the dose was gradually increased to the load dosage of methylprednisolone.Results：The average remission time was（16±3.5） h in the treatment group and（27±4.7） h in the control group with significant difference between the two groups（P0.05）.Conclusion：Using the load dosage as the initial dose of methylprednisolone is beneficial to quickly remit persistent attack of adult asthma.