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中国人群几种主要HIV-1感染辅助受体和配体基因多态性分析 被引量:4

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摘要 一、概述HIV-1感染和艾滋病的发病过程除了由病毒本身的侵袭力决定外,人体(宿主)因素同样是不可忽视的重要方面。在HIV-1感染靶细胞的过程中,病毒不仅与CD4细胞结合,还必须和辅助受体结合,才能进入靶细胞。这意味着辅助受体等位基因发生缺失突变,将使机体在基因水平上对HIV-1感染及其病程的发展产生天然的阻抗[1-3]。
出处 《中国优生与遗传杂志》 2011年第10期127-130,共4页 Chinese Journal of Birth Health & Heredity
基金 云南省科技厅面上资助项目 项目编号:2008ZC150M
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参考文献21

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二级参考文献4

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同被引文献29

  • 1邓小玲 ,洪坤学 ,陈健平 ,阮玉华 ,许铭炎 ,秦光明 ,李克 ,邢辉 ,邵一鸣 .四川彝族人群HIV-1辅助受体CCR5△32和CCR2-64I基因多态性分析[J].中华流行病学杂志,2004,25(12):1050-1053. 被引量:15
  • 2邓小玲,洪坤学,陈健平,阮玉华,许铭炎,秦光明,邢辉,李克,邵一鸣.四川彝族人群HIV-1辅助受体CX3CR1基因多态性分析[J].癌变.畸变.突变,2006,18(6):420-422. 被引量:2
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