裴氏消风散联合碳酸氢钠治疗表阿霉素渗漏损伤的实验研究

The experimental study of the effect of Pei Xiao Feng Powder combined with sodium bicarbonate on epirubicin leakage injury

目的:探讨安全、有效的表阿霉素渗漏损伤最佳治疗方案。方法:将家兔12只制作成表阿霉素渗漏损伤模型,随机分为A、B、C、D组,每组3只。A组用3%碳酸氢钠1ml加5%地塞米松0.1mg作局部封闭、用裴氏消风散冷外敷;B组用0.1g/5ml利多卡因1ml作局部封闭后用硫酸镁湿敷;C组用0.1g/5ml利多卡因1ml作局部封闭后用烧伤膏外敷;D组用0.1g/5ml利多卡因1ml作局部封闭后冷敷。治疗后2天、7天取4组局部组织进行组织学检查,20天对局部皮肤损伤进行分度评价。结果:治疗后2天、7天四组局部组织进行组织学评价及20天局部皮肤损伤进行分度评价比较,差异有统计学意义(均P<0.01),以A组效果最优。结论:局部配合裴氏消风散联合碳酸氢钠地塞米松治疗组,具有减轻表阿霉素渗漏所致局部组织损伤及促进损伤修复的良好作用。

Objective： To explore the best option of safe and effective epirubicin leakage injury. Methods： Twelve rabbits which were made into epirubicin leakage injury model were randomly divided into group A, B, C and D. Group A applied cold Pei Xiao Feng Powder after local closure with 3% sodium bicarbonate plus 5% dexamethasone. Group B applied magnesium sulfate wet compress after closure with 0.1g/5mg lidocaine. Group C applied a topical burn ointment after closure with 0.1g/5mg lidocaine. Group D applied cold compress after closure with 0.1g/5mg lidocaine. We took local tissues for histological examination on 2 days and 7days after treatment and evaluated sub-degree of local skin injury on 20 days after treatment. Results： There were significant difference of histological evaluation of local organizations on 2 days and 7 days after treatment and sub-degree evaluation of local skin injury on 20 days after treatment （P 〈0.01）. Group A had best effect. Conclusion： Local Pei Xiao Feng Powder combined with dexamethasone sodium bicarbonate treatment could reduce local tissue damage and promote repair of epirubicin leakage injury.