费县全面实施儿童乙型肝炎疫苗免疫接种的效果分析

目的:评价费县全面实施乙型肝炎免疫接种的效果。方法:2009年10～12月抽取幼儿园、小学、初中各2所,对部分2～14岁儿童进行调查。结果:调查3819人,完成全程以上接种乙肝疫苗的91.10%,单纯HBsAg阳性检出率0.84%,乙肝患病率0.47%.全程以上接种率有随着年龄的增长而降低的趋势(P<0.01),单纯HBsAg阳性率,2～10岁、11～12岁、13～14岁分别为0.41%、1.43%、6.00%(P<0.01),乙肝患病率2～10岁0.10%,11～14岁1.64%(P<0.01),全面实施乙肝免疫后与实施前出生的,完成全程以上乙肝疫苗接种都所占比例分别为91.49%和62.00%(P<0.01),单项HBsAg阳性的分别占0.63%和6.00%(P<0.01),乙肝患病率分别为0.35%和3.33%。结论:全面实施乙肝疫苗接种可以降低儿童乙肝病毒感染率与乙肝发病率。

Objective：To evaluate the immunization effect of full implementation of hepatitis B vaccination in children in Yuncheng county. Methods ： Two kindergartens, primary and junior high schools were selected respectively from October to December in 2007 ,children aged from 2- 14 were investigated. Results ： Of the 3819 children investigated ,91.10% of the children were fully inoculated with hepatitis B vaccine. The detection rate of single HBsAg positive rate was 0.84%, The morbidity rate of hepatitis B was 0.47% ,The coverage of full immunization decreased along with the increase of the age（P 〈 0. 01 ）. Single HBsAg positive rate was 0.41%, 1.43% and 6. 00% in children aged from 2 - 10,11 - 12 and 13 - 14（P 〈0. 01 ）. The morbidity rate of hepatitis B was 0. 10% and 1.64% in children aged from2-10 and 11-14（P〈0.01）, The coverage of hepatitis B vaccine was 91.49% and 62.00% in the children born after full implementation of hepatitis B immunization and born before that. Single HBsAg positive rate accounted for 0. 63% and 6. 00% （ P 〈 0. 01 ） and the morbidity rate of hepatitis B was 0. 35% and 3.33%. Conclusion： The infection and morbidity rate of hepatitis B decreased after full implementation of hepatitis B immunization in children.