2000-2009年中国李斯特菌病文献报告病例分析

Listeriosis cases reported in medical literatures in China,2000-2009

目的描述中国(未包括香港、澳门和台湾地区,下同)近10年(2000.1-2009.12)来李斯特菌病的临床特征并简述其分布情况,为我国李斯特菌病的防治提供参考依据。方法计算机检索与手工检索结合收集我国2000.1-2009.12李斯特菌病的文献报告资料,从中提取各李斯特菌病例的临床与流行病学信息并进行统计分析。结果本文共纳入92例李斯特菌病例,其中,围生期病例54例,非围生期病例38例。李斯特菌病患者的临床表现以败血症(39%)最为多见,孕妇患者约91%有发热症状(37.5～40℃)。纳入病例平均病死率为21%(19/89),其中,新生儿的病死率高达56%(14/25)。我国16个省(约50%)已有李斯特菌病例报告,报告病例多集中于北京、上海两地(57%)。结论 2000-2009年的10年,全国16个省在中文科技杂志上报告了92例李斯特菌病例。病例临床特征、报告病死率等与欧美国家类似。

Objective To describe the clinical and epidemiological features of listeriosis in China from 2000 to 2009 and provide evidence for improvement of listeriosis prevention and control.Methods The literatures about listeriosis in China from 2000 to 2009 were collected through electronic and manual search to conduct clinical and epidemiological analysis of listeriosis were included.Results A total of 92 clinical cases of listeriosis,including 54 cases in perinatal stage and 63 cases in non-perinatal stage.The main clinical manifestation of listeriosis was septicemia（39%）.The patients in pregnancy were more likely（91%） to have fever（37.5-40 ℃）.The average case fatality among the cases analyzed was 21%（19/89）,but the case fatality in the neonates was as high as 56%（14/25）.Cases were reported in half of the provinces in China,but most often（57%） in Shanghai and Beijing.Conclusion The clinical and epidemiological features and case fatality of listeriosis in China were similar to those in European and American countries.