苦参碱衍生物的合成及抗肿瘤活性测试

Synthesis and Biological Evaluation of Matrine Derivatives as Anticancer Agents

以苦参碱为原料合成去氧苦参碱和苦参酸。其结构经EI-MS1、H NMRI、R和元素分析确证。采用MTT法测试所合成化合物的体外抗肿瘤活性,结果表明,去氧苦参碱抗肝癌细胞HepG2和SMMC7721的活性强于苦参碱。

Two matrine derivatives were synthesized,their structures were confirmed by MS,IR,and 1H NMR spectra.The biological evaluation showed that compound deoxy-matrine had stronger cytotoxic activities than maitrine against human hepatoma cells（Hep G2 and SMMC 7721） in vitro by MTT method.