骨髓间充质干细胞向雪旺细胞诱导分化方法的研究进展

Research progress on differentiation of bone marrow stem cell into Schwann cells

细胞移植技术治疗周围神经损伤已成为新兴的组织工程学研究热点。骨髓间充质干细胞（BMSCs），由于其具有扩增快、便于分离提纯、可以体外诱导分化成为雪旺细胞（sc）的特性，有可能成为雪旺细胞的有效替代品和组织工程化神经的新型种子细胞。就种子细胞雪旺细胞和骨髓间充质干细胞的生理功能、生物学特性、体外诱导骨髓问充质干细胞生成雪旺细胞的方法以及研究前景作一综述。

Applying cellular transplant methods in the treatment of peripheral nerve injury has become a new hot spot in tissue engineering and drawn much attention. Bone marrow stromal cells （BMSCs） grow fast and can be easily purified in vitro. Besides, they have the capability of differentiating into Schwann cells under specific conditions. For all the reasons above, BMSCs are considered good succedaneum of Schwann cells and new seed cells for tissue engineered peripheral nerve. In this review, the physiological functions and bionomics of Schwann ceils and BMSCs are introduced, as well as various methods inducing BMSCs into nerve tissue cells and the foreground of the research.